公开(公告)号：WO2022265679A2

公开(公告)日：2022-12-22

申请号：PCT/US2022/000011

申请日：2022-06-17

申请人： NAMMI THERAPEUTICS, INC.

发明人： STOVER, David ,  MORRISON, Sherie ,  VASUTHASAWAT, Alex ,  TRIHN, Kham

IPC分类号： A61K38/21 ,  A61K47/68 ,  A61P35/00 ,  C07K7/08 ,  C07K14/56 ,  C07K16/28 ,  A61K38/212 ,  A61K47/6811 ,  A61K47/6849 ,  C07K16/2896 ,  C07K2319/33

摘要： Fusion Protein compositions comprising masked IFNs and methods of making masked IFNs are disclosed herein. Consequently, the masked IFNs can be fused to a Mab or binding fragment thereof and be administered to patients as a therapeutic modality and provide a method of treating cancer, immunological disorders and other disease.