公开(公告)号：WO2018220588A1

公开(公告)日：2018-12-06

申请号：PCT/IB2018/053923

申请日：2018-05-31

Applicant: NESTEC S.A.

Inventor： JAIN, Anjali ,  KONDRAGUNTA, Venkateswarlu ,  HALE, Michael

IPC: G01N33/68 ,  G01N33/564

Abstract: The present disclosure provides methods for assessing mucosal healing in a patient with Crohn's Disease. The methods include detecting expression levels of analytes in a serum sample from a patient, and applying a mathematical algorithm to the expression levels, thereby producing a Mucosal Healing Index score for the patient. The present disclosure also provides kits that include two or more binding partners, each or which is capable of binding a different analyte measured in the disclosed mucosal healing assessment methods.

公开(公告)号：WO2018130988A1

公开(公告)日：2018-07-19

申请号：PCT/IB2018/050212

申请日：2018-01-12

Applicant: NESTEC S.A.

Inventor： HALE, Michael ,  RIDEOUT, Darryl ,  SRIKRISHNAN, Raj ,  WESTIN, Stefan ,  SCHMIT, David

IPC: C07D487/08 ,  C07F5/00 ,  A61K49/00 ,  G01N33/533

Abstract: The present invention provides cryptates derivatives of formula (I) and conjugates thereof with excellent fluorescent properties. The cryptates are useful in biological assays and methods for the detection and identification of various analytes.