公开(公告)号：WO2018104426A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/081783

申请日：2017-12-07

申请人： NESTLÉ SKIN HEALTH SA

发明人： ÖHRLUND, Åke ,  KARLSSON, Morgan

IPC分类号： G01N11/16 ,  A61K31/728 ,  G01N11/00

摘要： The present invention provides a process for evaluating rheological characteristics of an injectable gel comprising measuring the flexibility, wherein the flexibility is evaluated by measuring the strain at the crossover point of the amplitude sweep. As an example, the process may comprise subjecting an injectable gel to oscillating mechanical stresses to determine G' and G" as a function of strain (γ) in an amplitude sweep, determining the crossover point as the point at which G' and G" have the same value, determining the strain Ycrass at the crossover point, and determining the flexibility of the injectable gel as Ycrass or proportional to Ycross. The present invention further provides a method of comparison of dermal fillers by measuring their flexibility and a method of evaluation of dermal filler behavior in human skin by measuring the flexibility according to the previous claims.

公开(公告)号：WO2019121688A1

公开(公告)日：2019-06-27

申请号：PCT/EP2018/085504

申请日：2018-12-18

申请人： NESTLÉ SKIN HEALTH SA

发明人： ÖHRLUND, Åke ,  KARLSSON, Morgan

IPC分类号： C08J3/075 ,  C08J3/24 ,  C08L5/08 ,  A61L27/52 ,  C08J3/12 ,  A61L27/26 ,  A61L27/48

CPC分类号： C08J3/075 ,  A61L27/26 ,  A61L27/48 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61L2430/40 ,  C08B37/0063 ,  C08B37/0072 ,  C08J3/126 ,  C08J3/245 ,  C08J2305/08 ,  C08J2405/08 ,  C08L5/08

摘要： The present invention provides a method of producing an injectable gel product, comprising the steps of a) cross-linking a first glycosaminoglycan (GAG) with a first crosslinking agent to produce a gel, wherein the charging ratio of crosslinking agent to disaccharide unit is below 0.15; b) preparing particles of the gel from step a); c) mixing the glycosaminoglycan (GAG) gel particles of step b) with a second glycosaminoglycan (GAG) to provide a mixture; d) cross-linking the mixture of step c) with a second crosslinking agent to obtain cross-linking between the glycosaminoglycans (GAGs) of the second, outer phase, thereby providing a gel having a first, inner phase of the cross-linked glycosaminoglycan (GAG) gel particles, embedded in a gel of the second, outer phase comprising the second glycosaminoglycan (GAG), and e) preparing injectable particles of the gel from step d), each such particle containing a plurality of the cross-linked GAG gel particles of the first, inner phase. The present invention further provides an injectable gel product, an aqueous composition, and a pre-filled syringe.