公开(公告)号：WO2014035977A1

公开(公告)日：2014-03-06

申请号：PCT/US2013/056815

申请日：2013-08-27

Applicant: OHIO STATE INNOVATION FUNDATION

Inventor： REZAI, Ali, R. ,  FUNAI, Edward ,  LOCKWOOD, Charles

IPC: A61N1/32 ,  A61N1/36 ,  A61N1/04

CPC classification number: A61K38/4893 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/00 ,  A61N1/0456 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/36007 ,  A61N1/36014 ,  A61N1/3606 ,  A61N2/006

Abstract: A closed-loop therapy delivery system for modulating uterine function in a mammal can include: at least one electrode configured to deliver an electric current to a spinal cord target associated with uterine function; a power source in electrical communication with the at least one electrode; at least one sensor in electrical communication with the at least one electrode; and a controller in electrical communication with each of the at least one electrode and the at least one sensor. The controller can be configured to automatically coordinate operation of the power source. The controller can be configured to direct delivery of the electric current to the at least one electrode to deliver a therapy signal to the spinal cord target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby modulate uterine function.

Abstract translation: 用于调节哺乳动物子宫功能的闭环治疗递送系统可以包括：至少一个电极，被配置为将电流传递到与子宫功能相关联的脊髓靶标; 与所述至少一个电极电连通的电源; 至少一个与所述至少一个电极电连通的传感器; 以及与所述至少一个电极和所述至少一个传感器中的每一个电连通的控制器。 控制器可以配置为自动协调电源的运行。 控制器可以被配置为将电流传送到至少一个电极，以将治疗信号以足以实现哺乳动物的交感神经和/或副交感神经活动变化的量和足够长的时间递送到脊髓靶标 从而调节子宫功能。