公开(公告)号：WO2021010492A1

公开(公告)日：2021-01-21

申请号：PCT/JP2020/028771

申请日：2020-07-16

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： KAKUUCHI, Akito ,  UMEMURA, Shuhei ,  SVENSSON, Mats ,  RAVINSKY, Anatoly ,  INOYAMA, Daigo ,  KRILOV, Goran ,  TAKAHASHI, Hidenori ,  KONZE, Kyle ,  VERRAS, Andreas ,  CRUMPLER, Simon ,  VALLADE, Maelle ,  MACLEOD, Calum ,  SANDERSON, James N. ,  BULL, Richard J. ,  GAINES, Simon

IPC分类号： A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D261/08 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10 ,  C07D231/06 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/424 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53

摘要： The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, or Alzheimer's disease and the like.

公开(公告)号：WO2021223699A1

公开(公告)日：2021-11-11

申请号：PCT/CN2021/091843

申请日：2021-05-06

申请人： ONO PHARMACEUTICAL CO., LTD. ,  WUXI APPTEC (SHANGHAI) CO., LTD.

发明人： KAKUUCHI, Akito ,  UMEMURA, Shuhei ,  ASADA, Masaki ,  RUVINSKY, Anatoly ,  ZHANG, Yan ,  TAKAHASHI, Hidenori ,  KRILOV, Goran ,  INOYAMA, Daigo ,  KONZE, Kyle ,  SVENSSON, Mats

IPC分类号： C07D403/12 ,  A61P25/28 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/4245 ,  A61P35/00 ,  C07D403/14 ,  C07D413/14

摘要： The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (I) : wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.