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公开(公告)号：WO2022051060A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/045150
申请日：2021-08-09
Applicant: ORTHOGENRX, INC.
Inventor： MENCEL, James, J. , TOLEDO-VELASQUEZ, David , DALEY, Michael, Joseph
Abstract: The present invention provides a non-animal derived, such as non-avian derived hyaluronic acid (HA) that has a molecular weight of about 500 to about 16000 kD, preferably about 500 kDa to about 10000 kDa. Most preferred HAs have a molecular weight of about 3000 kDa to about 6000 kDa. This HA is DVS cross-linked, water soluble and stable over time. The presently provided HA is free from the immunogenic proteins that are found in animal derived HAs. Further, the HAs of the present invention are microbiologically-derived or chemically synthesized, yet cross-linked to remain water soluble and stable over a period of time. Preparation of cross-linked HA' s of the invention using non-animal derived HA avoids the negative immunologic reactions observed for previously described animal derived cross -linked HAs.
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