公开(公告)号：WO1997033604A1

公开(公告)日：1997-09-18

申请号：PCT/US1997003819

申请日：1997-03-12

Applicant: PICOWER INSTITUTE FOR MEDICAL RESEARCH

Inventor： PICOWER INSTITUTE FOR MEDICAL RESEARCH ,  BUKRINSKY, Michael ,  SHERRY, Barbara, A. ,  ULRICH, Peter, C. ,  CERAMI, Anthony

IPC: A61K38/13

CPC classification number: C07K16/40 ,  A61K38/13 ,  A61K38/52

Abstract: There is disclosed pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner as a target for intervention. There is further disclosed a method of using cyclophilins, anti-cyclophilin antibodies, and pegylated cyclosporin A as a treatment for HIV-infection. The present invention further provides screening assays for the identification of compounds which inhibit the interaction of cyclophilin and its cellular receptor.

Abstract translation: 公开了使用亲环蛋白A及其相应的人细胞结合配偶体作为干预靶标来治疗HIV感染的药物组合物。 还公开了使用亲环蛋白，抗亲环蛋白抗体和聚乙二醇化环孢菌素A作为HIV感染治疗的方法。 本发明进一步提供了用于鉴定抑制亲环蛋白及其细胞受体的相互作用的化合物的筛选试验。