公开(公告)号：WO2014195949A1

公开(公告)日：2014-12-11

申请号：PCT/IL2014/050504

申请日：2014-06-03

Applicant: PIMS PASSIVE IMAGING MEDICAL SYSTEMS LTD

Inventor： BEN-ZION, Dekel ,  ZILBERMAN, Arkadi ,  KLEIN, Ronnie ,  COHEN, Yaniv ,  BLAUNSTEIN, Nathan

IPC: G01N21/55 ,  G01N21/85

CPC classification number: G01N21/552 ,  C03C25/10 ,  G01N21/8507 ,  G01N2021/8542 ,  G02B6/02328 ,  G02B6/032 ,  G02B6/262

Abstract: A hybrid Attenuated Total Reflection fiber optic probe device having a radiation source; a detecting system; a core-only solid optical fiber probe tip having an input end and an output end; an input hollow fiber waveguide configured for association with the radiation source at a first end and interconnection with the input end of the core-only solid optical fiber probe tip at a second end; an output hollow fiber waveguide configured for interconnection with the output end of the core-only solid optical fiber probe tip at a first end and association with the detection system at a second end; an inwardly tapered solid fiber input radiation collector element configured at a tapered end for interconnection with the second end of the output hollow fiber waveguide so as to receive radiation from the radiation source; wherein an outside diameter of the core-only solid optical fiber probe tip and an inside diameter of each one of the input hollow fiber waveguide and the output hollow fiber waveguide is such that the interconnection between each one of the input hollow fiber waveguide and the output hollow fiber waveguide and the core-only solid optical fiber probe tip is by means of inserting the input end of the core-only solid optical fiber probe tip into the second end of the input hollow fiber waveguide and inserting the output end of the core-only solid optical fiber probe tip into the first end of the output hollow fiber waveguide, such that the core-only solid optical fiber probe tip is held in the input and output hollow fiber waveguides by means of friction, and wherein an outside diameter of a portion of the inwardly tapered solid fiber input radiation collector element and an inside diameter of the second end of the output hollow fiber waveguide is such that the tapered end of the inwardly tapered solid fiber input radiation collector element is held in the end of the second end of the output hollow fiber waveguide by means of friction.

Abstract translation: 具有辐射源的混合衰减全反射光纤探针装置; 检测系统; 仅具有输入端和输出端的仅芯固体光纤探针尖端; 输入中空纤维波导，其被配置为在第一端处与所述辐射源相关联并且在所述第二端与所述仅芯的固体光纤探针尖端的输入端互连; 输出中空纤维波导，其被配置为在第一端与仅芯芯固体光纤探针尖端的输出端相互连接，并在第二端与检测系统相关联; 配置在锥形端的向内锥形的固体光纤输入辐射收集器元件，用于与输出中空纤维波导的第二端互连，以便接收来自辐射源的辐射; 其中仅芯芯固体光纤探针尖端的外径和输入中空纤维波导和输出中空纤维波导中的每一个的内径使得输入中空纤维波导和输出中空纤维波导中的每一个之间的互连 中空纤维波导和仅芯固体光纤探针尖端是通过将仅核心固体光纤探针尖端的输入端插入输入中空纤维波导的第二端，并插入芯 - 只有固体光纤探针尖端进入输出中空纤维波导的第一端，使得仅芯的固体光纤探针尖端通过摩擦保持在输入和输出中空纤维波导中，并且其中外径 向内锥形的固体光纤输入辐射收集器元件的一部分和输出中空纤维波导的第二端的内径使得内向 锥形固体光纤输入辐射收集器元件通过摩擦保持在输出中空纤维波导的第二端的端部。

公开(公告)号：WO2018008025A1

公开(公告)日：2018-01-11

申请号：PCT/IL2017/050750

申请日：2017-07-05

Applicant: PIMS- PASSIVE IMAGING MEDICAL SYSTEMS LTD

Inventor： COHEN, Yaniv ,  DEKEL, Ben Zion ,  ZILBERMAN, Arkadi ,  BLAUNSTEIN, Nathan

IPC: A61B5/00 ,  G01N21/00 ,  G01N21/35 ,  G01N21/3563 ,  G01J3/42

Abstract: A device for real-time tissue diagnosis of biological tissue having: a means for preparing a tissue sample before a measurement procedure; a means for positioning an ATR element and mirrors so as to perform a system calibration; a means for irradiating a sample with IR radiation using the ATR element and an opto-mechanical assembly; a means for recording the absorption spectrum of a sample being tested; a means for carrying out a Fourier transformation of the absorption spectrum obtained into a FT-IR spectrum; a means for calculating tissue characteristics on the basis of signal processing; a means for comparing the characteristics in a pre-selected wavenumber range with the reference spectra prepared and stored in a database. Also, a method for real-time tissue diagnosis of biological tissue having solely the following steps: setting operating parameters: scanning ambient background air to obtain a background spectrum; placing a tissue under test in tight contact with an ATR; drying the tissue so as to at least reduce moisture content of the tissue sample; automatically adjusting at least one system mirror thereby performing a system calibration; and obtaining a spectrum of the tissue sample.

Abstract translation: 一种用于生物组织的实时组织诊断的装置，其具有：用于在测量过程之前制备组织样本的装置; 用于定位ATR元件和反射镜以执行系统校准的装置; 使用ATR元件和光机械组件用IR辐射照射样品的装置; 用于记录正在测试的样品的吸收光谱的装置; 用于将所获得的吸收光谱进行傅里叶变换为FT-IR光谱的装置; 用于基于信号处理来计算组织特征的装置; 用于比较预选波数范围中的特征与制备并存储在数据库中的参考光谱的装置。 另外，一种生物组织实时组织诊断的方法，其具体步骤如下：设置操作参数：扫描环境背景空气获得背景光谱; 将待测组织与ATR紧密接触放置; 干燥组织以至少降低组织样本的含水量; 自动调节至少一个系统反射镜，从而执行系统校准; 并获得组织样本的光谱。