公开(公告)号：WO2019155352A1

公开(公告)日：2019-08-15

申请号：PCT/IB2019/050889

申请日：2019-02-05

申请人： PIRAMAL ENTERPRISES LIMITED

发明人： GHARPURE, Milind ,  SHARMA, Sanjay Kumar ,  KANSAGARA, Nainesh ,  ZALTE, Yogesh ,  THOMBRE, Pravin ,  MENON, Sudha

IPC分类号： C07D295/096

摘要： The present invention relates to a novel crystalline polymorphic form of 1-[2-(2,4-dimethyl- phenylsulfanyl)-phenyl]-piperazine hydrochloride; commonly known as vortioxetine hydrochloride (hereafter referred to as the compound (Ia) and process for its preparation comprising of treating the compound (Ia) (as described herein) with a ketone solvent or mixture of ketone solvent with other solvents. The present invention also relates to an improved process for the preparation of vortioxetine hydrobromide (Ia), comprising reacting the compound (I) (as described herein) with hydrogen bromide solution in acetic acid.