公开(公告)号：WO2014039514A2

公开(公告)日：2014-03-13

申请号：PCT/US2013/057992

申请日：2013-09-04

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： INGBER, Donald, E. ,  HAMILTON, Geraldine, A. ,  LEVNER, Daniel ,  HINOJOSA, Christopher ,  PATTERSON, Daniel

IPC: B01J4/00

CPC classification number: B01L3/502723 ,  B01D17/085 ,  B01D19/0031 ,  B01D63/088 ,  B01D71/36 ,  B01D2325/38 ,  B01L3/502715 ,  B01L2200/0684 ,  B01L2300/06 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  C12M23/16 ,  C12M23/24 ,  C12M23/36

Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.

Abstract translation: 微流体系统包括连接到气泡收集装置的微流体装置，由此流入微流体装置的流体在进入微流体装置之前穿过气泡收集装置以去除气泡。 气泡捕集器可以包括由疏水性多孔膜隔开的分离室和排气室，当流体保留在分离室中时，进入分离室的流体中的气泡穿过疏水性多孔膜进入排气室。 气泡捕集器可通过将第一主体部分结合到疏水性多孔膜的第一侧并将第二主体部分结合到疏水性多孔膜的第二侧来形成。 排气室可连接到细长的排气通道，该排气通道限制流体通过疏水性多孔膜的蒸发损失。