公开(公告)号：WO2014075033A3

公开(公告)日：2014-10-30

申请号：PCT/US2013069545

申请日：2013-11-12

Applicant: PUGET SOUND BLOOD CT

Inventor： CHUNG DOMINIC ,  LOPEZ JOSE ARON ,  LING MINHUA ,  CHEN JUNMEI ,  FU XIAOYUN

IPC: A61K38/00 ,  A61L29/00

CPC classification number: A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61L29/048 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L31/10 ,  A61L31/143 ,  A61L31/16 ,  A61L2300/424 ,  A61L2400/18 ,  C07K14/755 ,  C07K14/775

Abstract: Compositions and methods are described for preventing or reducing protein loss due to protein aggregation, denaturation, and absorption to surfaces. Also described are compositions and methods for preventing or reducing the fouling or clogging of medical devices that come into contact with blood, such as catheters. Also described are methods to treat diseases caused by activation of the microvasculature.

Abstract translation: 描述了用于预防或减少由于蛋白质聚集，变性和表面吸收引起的蛋白质损失的组合物和方法。 还描述了用于防止或减少与血液接触的医疗装置例如导管的结垢或堵塞的组合物和方法。 还描述了治疗由微血管激活引起的疾病的方法。