公开(公告)号：WO2012054758A2

公开(公告)日：2012-04-26

申请号：PCT/US2011057147

申请日：2011-10-20

Applicant: RAPID DIAGNOSTEK INC ,  JOHAL GAGANBIR SINGH ,  HARMON IAN ROBERT ,  VAN DEUSEN RICHARD ALLAN

Inventor： JOHAL GAGANBIR SINGH ,  HARMON IAN ROBERT ,  VAN DEUSEN RICHARD ALLAN

IPC: G01N29/02 ,  G01N11/16 ,  G01N33/483

CPC classification number: G01N33/557 ,  G01N24/00 ,  G01N29/022 ,  G01N29/036 ,  G01N33/54373 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

Abstract: Apparatus and method for detecting a presence of a subject material in a fluid sample using at least one resonating sensor immersible in the fluid sample. Binding kinetics of an interaction of an analyte material present in the fluid sample are measured with the resonating sensor, which has binding sites for the analyte material. Prior to exposing the resonating sensor to the fluid sample, operation of the resonating sensor is initiated, which produces a sensor output signal representing a resonance characteristic of the resonating sensor. Optionally, a reference resonator is used that produces a reference output signal. The reference resonator lacks binding sites for the analyte. Introduction of a fluid sample to the resonating sensor is automatically detected based on detection of a characteristic change in the sensor output signal or a reference output signal, or both. In response to the detecting of the introduction of the fluid sample, automated measurement of the binding kinetics of the analyte material to the resonating sensor are measured.

Abstract translation: 使用浸没在流体样品中的至少一个谐振传感器来检测流体样品中的主题材料的存在的装置和方法。 存在于流体样品中的分析物质的相互作用的结合动力学用共振传感器测量，该传感器具有分析物质的结合位点。 在将共振传感器暴露于流体样品之前，启动谐振传感器的操作，其产生表示谐振传感器的谐振特性的传感器输出信号。 可选地，使用产生参考输出信号的参考谐振器。 参考共振器缺乏分析物的结合位点。 基于对传感器输出信号或参考输出信号的特性变化的检测，或两者都自动检测将流体样本引入谐振传感器。 响应于检测引入流体样品，测量分析物质与共振传感器的结合动力学的自动测量。

公开(公告)号：WO2016044055A1

公开(公告)日：2016-03-24

申请号：PCT/US2015049387

申请日：2015-09-10

Applicant: RAPID DIAGNOSTEK INC

Inventor： SALVATI MICHAEL ,  HARMON IAN ROBERT

IPC: G01N33/53 ,  G01N31/00 ,  G01N33/00

CPC classification number: G01N31/00 ,  G01N33/54373

Abstract: Sensitivity of thin film bulk acoustic resonance (TFBAR) sensors is enhanced by mass amplification and operating a high frequency.

Abstract translation: 薄膜体声共振（TFBAR）传感器的灵敏度通过质量放大和高频操作得到增强。