公开(公告)号：WO2021253030A2

公开(公告)日：2021-12-16

申请号：PCT/US2021/070634

申请日：2021-05-28

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REINEKE, Theresa ,  LE, Ngoc ,  TAN, Zhe ,  KUMAR, Ramya

IPC: C08F220/20 ,  C08F220/28 ,  C08F220/34 ,  C08F230/02 ,  C08F293/00 ,  A61K47/58 ,  C12N15/87 ,  A61K9/51 ,  A61K49/00 ,  A61K9/5138 ,  A61P35/00 ,  C08F2/06 ,  C08F2/38 ,  C08F220/286 ,  C08F2438/03 ,  C08F293/005

Abstract: A compound includes a polymer associated with a biological agent. The polymer has a first (meth)acryl monomeric unit with a cationic functional group R1 and a second (meth)acryl monomeric unit with a neutral hydrophilic functional group R2. The cationic functional group R1 is chosen from amino groups and alkylamino groups, and the neutral functional group R2 is chosen from polyethylene glycol (PEG), hydroxyl (OH), phosphorylcholine (PC), and mixtures and combinations thereof.

公开(公告)号：WO2021253030A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/070634

申请日：2021-05-28

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA [US]/[US]

Inventor： REINEKE, Theresa ,  LE, Ngoc ,  TAN, Zhe ,  KUMAR, Ramya

IPC: C08F220/20 ,  C08F220/28 ,  C08F220/34 ,  C08F230/02 ,  C08F293/00 ,  A61K47/58 ,  C12N15/87 ,  A61K9/51 ,  A61K49/00 ,  A61K9/5138 ,  A61P35/00 ,  C08F2/06 ,  C08F2/38 ,  C08F220/286 ,  C08F2438/03 ,  C08F293/005

Abstract: A compound includes a polymer associated with a biological agent. The polymer has a first (meth)acryl monomeric unit with a cationic functional group R1 and a second (meth)acryl monomeric unit with a neutral hydrophilic functional group R2. The cationic functional group R1 is chosen from amino groups and alkylamino groups, and the neutral functional group R2 is chosen from polyethylene glycol (PEG), hydroxyl (OH), phosphorylcholine (PC), and mixtures and combinations thereof.