公开(公告)号：WO1989012448A1

公开(公告)日：1989-12-28

申请号：PCT/US1989002706

申请日：1989-06-23

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： RESEARCH TRIANGLE INSTITUTE ,  COOK, C., Edgar ,  WANI, Mansukh, C. ,  LEE, Yue-Wei ,  REEL, Jerry, R. ,  RECTOR, Douglas

IPC: A61K31/56

CPC classification number: C07J41/0083 ,  C07J7/002 ,  C07J7/0045 ,  C07J13/005 ,  C07J53/004 ,  C07J71/0052

Abstract: An 11 beta -aryl-19-norprogesterone steroid of formula (I): wherein (i) R is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R , wherein R is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R is H, C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl, R is H, CH3, F or Cl, R is H, (CH3)2N, CH3O, CH3CO, CH3S, CH3SO, CH3SO2, and X is O or NOCH3; or (ii) R and R taken together are a carbon-carbon bond and R , R , R and X are as defined above; or (iii) R and R taken together are -CH2- or -N=N-CH2-, R is H and R , R and X are as defined above; or (iv) R and R taken together are =CH2 and R , R , R and X are as defined above.

Abstract translation: 式（I）的11β-芳基-19-去甲孕酮类固醇：其中（i）R 1是H，C 1-4烷基，C 2-4烯基，C 2-4炔基，OH，OC（O）CH 3， 或OC（O）R 5，其中R 5是C 2-8烷基，C 2-8烯基，C 2-8炔基或芳基，R 2是H，R 3是H，C 1-4烷基，C 2 -4-烯基或C 2-4炔基，R 4是H，CH 3，F或Cl，R 6是H，（CH 3）2 N，CH 3 O，CH 3 CO，CH 3 S，CH 3 SO，CH 3 SO 2，X是O或NOCH 3 ; 或（ii）R 1和R 2一起是碳 - 碳键，R 3，R 4，R 6和X如上所定义; 或（iii）R 1和R 3一起是-CH 2 - 或-N = N-CH 2 - ，R 2是H且R 4，R 6和X如上所定义 ; 或（iv）R 2和R 3一起为= CH 2且R 1，R 4，R 6和X如上所定义。