公开(公告)号：WO02079778A3

公开(公告)日：2003-07-10

申请号：PCT/US0203984

申请日：2002-02-07

Applicant: RHEOLOGICS INC

Inventor： KENSEY KENNETH

IPC: A61B5/029 ,  A61K31/00 ,  A61K47/48 ,  A61K49/00 ,  A61M1/36 ,  A61P7/00 ,  A61P9/00 ,  G01N33/49 ,  G01N35/00 ,  G01N35/08

CPC classification number: A61B5/6866 ,  A61B5/02035 ,  A61B5/029 ,  A61K47/6957 ,  A61K49/0004 ,  A61M1/361 ,  A61M1/3672 ,  A61M2230/04

Abstract: Various methods are provided for determining and utilizing the viscosity of the circulating blood of a living being over a range of shear rates for diagnostics and treatment, such as detecting/reducing blood viscosity, work of the heart, contractility of the heart, for detecting/reducing the surface tension of the blood, for detecting plasma viscosity, for explaining/countering endothelial cell dysfunction, for providing high and low blood vessel wall shear stress data, red blood cell deformability data, lubricity of blood, and for treating different ailments such as peripheral arterial disease in combination with administering to a living being at least one pharmaceutically acceptable agent. Agents pharmaceutically effective to regulate at least one of the aforementioned blood parameters are used to adjust distribution of a substance through the bloodstream.

Abstract translation: 提供了各种方法用于确定和利用活体的循环血液的粘度，用于诊断和治疗的剪切速率范围，例如检测/降低血液粘度，心脏功，心脏收缩力，用于检测/ 减少血液的表面张力，检测血浆粘度，解释/对抗内皮细胞功能障碍，提供高和低血管壁剪切应力数据，红细胞变形性数据，血液润滑性和用于治疗不同疾病例如 外周动脉疾病与至少一种药学上可接受的药剂一起给予生物。 药学上有效调节至少一种前述血液参数的药物用于调节物质通过血流的分布。

公开(公告)号：WO0243806A3

公开(公告)日：2003-03-27

申请号：PCT/US0144352

申请日：2001-11-27

Applicant: RHEOLOGICS INC

Inventor： KENSEY KENNETH ,  HOKANSON CHARLES

IPC: A61B5/029 ,  A61K31/00 ,  A61K47/48 ,  A61K49/00 ,  A61M1/36 ,  A61P7/00 ,  A61P9/00

CPC classification number: A61B5/02035 ,  A61B5/02028 ,  A61B5/029 ,  A61K47/6957 ,  A61K49/0004 ,  A61M1/361 ,  A61M1/3672 ,  A61M2230/04

Abstract: Various methods are provided for determining and utilizing the viscosity of the circulating blood of a living being over a range of shear rates for diagnostics and treatment, such as detecting/reducing blood viscosity, work of the heart, contractility of the heart, for detecting/reducing the surface tension of the blood, for detecting plasma viscosity, for explaining/countering endothelial cell dysfunction, for providing high and low blood vessel wall shear stress data, red blood cell deformability data, lubricity of blood, and for treating different ailments such as peripheral arterial disease in combination with administering to a living being at least one pharmaceutically acceptable agent. Agents pharmaceutically effective to regulate at least one of the aforementioned blood parameters are used to adjust distribution of a substance through the bloodstream.

Abstract translation: 提供了各种方法来确定和利用生物的循环血液的粘度在用于诊断和治疗的剪切速率范围内，例如检测/降低血液粘度，心脏的工作，心脏的收缩性，用于检测/ 降低血液的表面张力，用于检测血浆粘度，用于解释/抵抗内皮细胞功能障碍，用于提供高和低血管壁剪切应力数据，红细胞变形性数据，血液润滑性和用于治疗不同疾病，例如 外周动脉疾病与给予至少一种药学上可接受的药剂的生物相结合。 用于调节至少一种上述血液参数的药剂有效地用于调节物质通过血流的分布。

公开(公告)号：WO0218907A3

公开(公告)日：2003-02-27

申请号：PCT/US0125005

申请日：2001-08-09

Applicant: RHEOLOGICS INC ,  KENSEY KENNETH ,  HOGENAUER WILLIAM N ,  SHIN SEHYUN ,  KIM SANGHO ,  CHO YOUNG

Inventor： KENSEY KENNETH ,  HOGENAUER WILLIAM N ,  SHIN SEHYUN ,  KIM SANGHO ,  CHO YOUNG

IPC: G01N11/00 ,  G01N11/04 ,  G01N11/06 ,  A61B5/145

CPC classification number: A61B5/02035 ,  G01N11/04

Abstract: A scanning rheometer (20) is presented for the rheological property measurement of electrorheological (ER) and magnetorheological (MR) fluids using a non-linear viscoplastic model, based on the fluid height variation with respect to time. The rheometer basically includes a static (e.g., an overhead reservoir) or a dynamic source of fluid (22), a channel or slit (28) whose sides form electrodes (26) which are in contact with the flowing ER fluid, or a capillary tube (28) exposed to a static/alternating magnetic field (26) for flowing MR fluids, a transfer tube (29), either one or two riser tubes (R1,R2), and a column level detector (32) for monitoring the column of fluid as it moves in one of the riser tubes (R2). The column level detector (32) is coupled to a processor (34) which analyzes, among other things, column height vs. time data to determine both viscosity and yield stress. The rheometer overcomes one of the major drawbacks of the conventional rheometer: the inability to produce the yield stress of the ER, or MR, fluid in an absolute zero shear rate range. The results with this rheometer are compared with those obtained from a commercially-available rheometer which indicates excellent agreement.

Abstract translation: 基于相对于时间的流体高度变化，使用非线性粘弹性模型提供扫描流变仪（20）用于电流变学（ER）和磁流变（MR）流体的流变性质测量。 流变仪基本上包括静态（例如，顶部储存器）或动态流体源（22），其侧面形成与流动的ER流体接触的电极（26）的通道或狭缝（28），或毛细管 暴露于用于流动MR流体的静态/交变磁场（26）的管（28），一个或两个提升管（R1，R2）的传输管（29）和用于监测 一列流体在其一个提升管（R2）中移动时。 列级检测器（32）耦合到处理器（34），其处理塔高度与时间数据，以确定粘度和屈服应力。 流变仪克服了常规流变仪的主要缺点之一：不能在绝对零剪切速率范围内产生ER或MR流体的屈服应力。 将该流变仪的结果与从商业可得的流变仪获得的结果进行比较，这表明出色的一致性。

公开(公告)号：WO02078544A3

公开(公告)日：2003-02-06

申请号：PCT/US0204378

申请日：2002-02-14

Applicant: RHEOLOGICS INC ,  KENSEY KENNETH ,  HOGENAUER WILLIAM N

Inventor： KENSEY KENNETH ,  HOGENAUER WILLIAM N

IPC: A61M1/02 ,  G01N11/04 ,  A61B5/145

CPC classification number: A61M1/025 ,  A61M1/0254 ,  G01N11/04

Abstract: A method and apparatus for testing the efficacy of agents (e.g., new drugs, old drugs, biologically-active agents, etc.) by removing a predetermined amount of blood from a living being and placing this predetermined amount of blood in continuous motion in a temperature-controlled environment and then removing samples from the continuously-moving predetermined amount of blood. The drug, or drugs, or agents under test can then be administered to the removed samples, instead of into the living being, thereby avoiding subjecting the living being to any risk of any adverse reaction while utilizing blood samples that simulate the circulating blood of the living being.

Abstract translation: 一种用于通过从活体中除去预定量的血液并将该预定量的血液连续运动放置在试管中来测试药剂（例如新药，老药，生物活性剂等）的功效的方法和装置 温度控制环境，然后从连续移动的预定量的血液中取出样品。 然后可以将药物或药物或被试药物施用于去除的样品，而不是进入生物体，从而避免使生物受到任何不良反应的风险，同时利用模拟循环血液的血液样品 生活在

公开(公告)号：WO03008936A2

公开(公告)日：2003-01-30

申请号：PCT/US0222732

申请日：2002-07-17

Applicant: RHEOLOGICS INC

Inventor： KENSEY KENNETH ,  HOGENAUER WILLIAM N ,  CHO YOUNG I ,  SHIN SEHYUN ,  KIM SANGHO

IPC: G01N11/06 ,  G01N13/02

CPC classification number: G01N11/06 ,  G01N13/02

Abstract: A method and apparatus for determining the viscosity of a non-Newtonian fluid over plural shear rates using a single capillary tube exposed to a continuously decreasing pressure differential and while minimizing the effects of surface tension of that fluid during the determination. A particular application of this method and apparatus is also provided for determining the viscosity of the blood of a living being whereby the single capillary tube initially forms a portion of a hand-held unit that obtains a portion of the circulating blood of the living being; the filled capillary tube is then ejected into an analyzer where the blood therein is exposed to the continuously decreasing pressure differential. Data is generated from the movement of the blood through the capillary tube, due to the decreasing pressure differential, and the blood viscosity is determined from that data.

Abstract translation: 一种用于使用暴露于连续降低的压力差的单个毛细管确定多个剪切速率的非牛顿流体的粘度并同时最小化在确定期间该流体的表面张力的影响的方法和装置。 还提供了该方法和装置的特定应用，用于确定生物的血液的粘度，由此单个毛细管最初形成获得生物的循环血液的一部分的手持单元的一部分; 然后将填充的毛细管喷射到其中其中的血液暴露于连续降低的压力差的分析器中。 数据是由血液通过毛细血管的运动而产生的，由于压力差减小，并且根据该数据确定血液粘度。