公开(公告)号：WO2013098655A3

公开(公告)日：2013-07-04

申请号：PCT/IB2012/003114

申请日：2012-11-01

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA, Mary, Jane ,  JAMILUDDIN, Mohamad, Fakruddin ,  HAMID, Sharifah, Binti

IPC: A61K39/125 ,  A61K39/13 ,  A61K39/135

Abstract: The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enteroviru s A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.

公开(公告)号：WO2015028888A2

公开(公告)日：2015-03-05

申请号：PCT/IB2014/002527

申请日：2014-08-25

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA, Mary, Jane ,  MONATH, Thomas

IPC: A61K39/42

CPC classification number: C07K16/1009 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/5258 ,  C12N2710/14143 ,  C12N2770/32323 ,  C12N2770/32334 ,  C12N2770/32623 ,  C12N2770/32634 ,  C12N2840/203 ,  Y02A50/466

Abstract: The invention provides materials and methods for a pharmaceutical composition comprising a polyclonal antibody preparation or a monoclonal antibody preparation or an antibody fragment preparation with or without a drug to prevent the infection of, or treat an infection of a subject by a Human Enterovirus, including, a Human Enterovirus responsible for foot, hand and mouth disease. The pharmaceutical composition includes a polyclonal antibody preparation or a monoclonal antibody preparation or an antibody fragment preparation to protect against or treat an infection by a Human Enterovirus, including, a Human Enterovirus responsible for foot, hand and mouth disease. The invention further provides for a method to use the pharmaceutical composition to protect against or treat an infection by a Human Enterovirus, including, a Human Enterovirus responsible for foot, hand and mouth disease as well as kits to do the same.

Abstract translation: 本发明提供了包含多克隆抗体制剂或单克隆抗体制剂或具有或不具有药物以防止人肠道病毒感染或治疗受试者感染的抗体片段制备物的药物组合物的材料和方法， 一种负责脚部，口腔疾病的人肠道病毒。 该药物组合物包括多克隆抗体制备物或单克隆抗体制剂或抗人体肠道病毒感染的抗体片段制备物，包括负责脚部，口腔疾病的人肠道病毒。 本发明进一步提供了使用该药物组合物来防止或治疗人肠道病毒感染的方法，所述人肠病毒包括负责足部，手部和口腔疾病的人肠道病毒以及进行相同操作的试剂盒。