公开(公告)号：WO2018066999A2

公开(公告)日：2018-04-12

申请号：PCT/MY2017/050059

申请日：2017-09-21

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA, Mary Jane

IPC: A61K39/125

CPC classification number: A61K39/125 ,  A61K39/13 ,  A61K39/135 ,  A61K2039/5258 ,  A61K2039/575 ,  A61K2039/70 ,  C12N2710/00034 ,  C12N2770/32322 ,  C12N2770/32323 ,  C12N2770/32334 ,  C12N2770/32371 ,  Y02A50/466

Abstract: The invention provides chimeric Enterovirus virus-like particles (VLPs) for protection and/or treatment against infection by more than one Enterovirus . More specifically, the present invention provides chimeric EV-A71 virus-like particles displaying CV-A16 VP1 polypeptides and at the same time maintaining important neutralizing antibody epitopes of EV-A71 itself. More specifically, the present invention provides chimeric CV-A16 virus-like particles displaying EV-A71 VP1 polypeptides. Thus, the present invention provides a bivalent vaccine comprising the chimeric virus-like particles which elicit an immune response and/or neutralizing antibody response to both EV-A71 and CVA-16 for the treatment of Hand, Foot and Mouth Disease.

Abstract translation: 本发明提供了用于防止和/或治疗超过一种肠道病毒的感染的嵌合型肠病毒样颗粒（VLP）。 更具体地说，本发明提供了展示CV-A16 VP1多肽的嵌合EV-A71病毒样颗粒，同时维持了EV-A71本身的重要中和抗体表位。 更具体地说，本发明提供了展示EV-A71 VP1多肽的嵌合CV-A16病毒样颗粒。 因此，本发明提供了包含嵌合病毒样颗粒的二价疫苗，所述嵌合病毒样颗粒对EV-A71和CVA-16两者引发免疫应答和/或中和抗体应答以治疗手足口病。

公开(公告)号：WO2018067000A1

公开(公告)日：2018-04-12

申请号：PCT/MY2017/050060

申请日：2017-09-21

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA, Mary Jane

IPC: A61K39/125 ,  A61K39/135

CPC classification number: A61K39/125 ,  A61K39/135 ,  A61P31/14 ,  C12N15/85 ,  C12N2710/10323 ,  C12N2770/32334 ,  C12N2770/32371 ,  Y02A50/466

Abstract: This invention relates to Virus-Like Particles (VLPs) derived from Enterovirus and vaccines comprising such VLPs which elicit immune responses and/or protective neutralizing antibody responses directed against an Enterovirus . The instant invention provides expression cassettes and methods for making Enterovirus CV-A16 VLPs and compositions enriched in CV-A16 VLPs which exhibit conformational epitopes which elicit immune responses and/or neutralizing antibody responses which may be used in vaccines directed against Enterovirus CV-A16.

Abstract translation: 本发明涉及源自肠道病毒的病毒样颗粒（VLP）和包含此类VLP的疫苗，所述VLP引发针对的免疫应答和/或保护性中和抗体应答 >肠道病毒的。 本发明提供了用于制备肠病毒CV-A16VLP的表达盒和方法，以及富含CV-A16VLP的组合物，其显示构象性表位，其引发可用于针对肠道病毒的疫苗中的免疫应答和/或中和性抗体应答 / i> CV-A16。