公开(公告)号：WO2013098655A2

公开(公告)日：2013-07-04

申请号：PCT/IB2012003114

申请日：2012-11-01

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA MARY JANE ,  JAMILUDDIN MOHAMAD FAKRUDDIN ,  HAMID SHARIFAH BINTI

IPC: A61K39/125

CPC classification number: A61K39/125 ,  A61K39/12 ,  A61K39/13 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2770/32323 ,  C12N2770/32334 ,  C12N2770/32351 ,  C12N2770/32371 ,  C12N2770/32634

Abstract: The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.

Abstract translation: 本发明提供了用于产生衍生自小核糖核酸病毒科病毒家族成员的免疫活性抗原的材料和方法。 本发明的小核糖核酸病毒抗原可以是用于在治疗性治疗中施用于受试者的疫苗或用于预防小RNA病毒感染的形式。 本发明的小核糖核酸病毒抗原可以是用于疫苗的免疫原性组合物的形式，其用于预防肠道病毒感染。 本发明还包括包含人肠道病毒A，人肠道病毒B，人肠病毒C，人肠道病毒D抗原及其在疫苗中用于预防肠道病毒感染的应用的免疫原性组合物。

公开(公告)号：WO2013098655A9

公开(公告)日：2013-12-19

申请号：PCT/IB2012003114

申请日：2012-11-01

Applicant: SENTINEXT THERAPEUTICS SDN BHD

Inventor： CARDOSA MARY JANE ,  JAMILUDDIN MOHAMAD FAKRUDDIN ,  HAMID SHARIFAH BINTI

IPC: A61K39/125 ,  A61K39/13 ,  A61K39/135

CPC classification number: A61K39/125 ,  A61K39/12 ,  A61K39/13 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2770/32323 ,  C12N2770/32334 ,  C12N2770/32351 ,  C12N2770/32371 ,  C12N2770/32634

Abstract: The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.

Abstract translation: 本发明提供了用于生产源自小核糖核酸病毒科病毒成员的免疫活性抗原的材料和方法。 本发明的小核糖核酸病毒抗原可以以用作治疗性治疗中的受治疗者或预防小核糖核酸病毒感染的疫苗的形式。 本发明的小核糖核酸病毒抗原可以是用于疫苗的免疫原性组合物的形式，其被施用用于预防肠道病毒感染。 本发明进一步涵盖包含人肠道病毒A，人肠道病毒B，人肠道病毒C，人肠道病毒D抗原的免疫原性组合物及其在疫苗中用于预防肠道病毒感染的用途。