公开(公告)号：WO2021114315A1

公开(公告)日：2021-06-17

申请号：PCT/CN2019/125455

申请日：2019-12-14

申请人： SHANGHAI EAST HOSPITAL

发明人： CHEN, Yihan ,  LIANG, Dandan ,  LIU, Yi ,  SAKYA, Subas Man ,  LI, Li ,  ZHANG, Fulei ,  ZHOU, Huixing ,  HE, Xiaoyu

IPC分类号： A61K31/4166 ,  A61K31/4178 ,  C07D233/96 ,  A61P9/00 ,  A61P9/10

摘要： Provided herein is the use of heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases. Specifically, disclosed is the use of compounds of formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a prodrug thereof; and application thereof. Definition of each group in the formula can be found in the specification for details.

公开(公告)号：WO2021114313A1

公开(公告)日：2021-06-17

申请号：PCT/CN2019/125453

申请日：2019-12-14

申请人： SHANGHAI EAST HOSPITAL

发明人： CHEN, Yihan ,  LIANG, Dandan ,  LIU, Yi ,  SAKYA, Subas Man ,  YANG, Jinhua ,  LI, Li ,  XIE, Duanyang ,  SHI, Dan ,  XIONG, Ke

IPC分类号： C07C15/24 ,  C07C15/16 ,  A61K31/015 ,  A61P9/06

摘要： Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.