公开(公告)号：WO2019139921A1

公开(公告)日：2019-07-18

申请号：PCT/US2019/012770

申请日：2019-01-08

Applicant: SHUTTLE PHARMACEUTICALS, INC.

Inventor： GRINDROD, Scott ,  JUNG, Mira ,  DRITSCHILO, Anatoly

IPC: A61K31/433 ,  C07C259/06 ,  C07D285/04

Abstract: Selective HDAC inhibitors, and pharmaceutical compositions that include the same, are described herein for the treatment of cancer, immunological diseases, inflammatory diseases, and neurological diseases.

公开(公告)号：WO2018129514A8

公开(公告)日：2018-07-12

申请号：PCT/US2018/012914

申请日：2018-01-09

Applicant: SHUTTLE PHARMACEUTICALS, INC.

Inventor： GRINDROD, Scott ,  TIMOFEEVA, Olga ,  BROWN, Milton ,  JUNG, Mira ,  DRITSCHILO, Anatoly

IPC: A61K31/505 ,  A61K31/513 ,  A61K31/7072

Abstract: Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.