公开(公告)号：WO2023017383A1

公开(公告)日：2023-02-16

申请号：PCT/IB2022/057301

申请日：2022-08-05

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： MACH, Tivadar ,  PAULICKA, Peter ,  SELIGER, Ramona ,  STELLING, Frederick

IPC: G01N33/49

Abstract: The disclosure relates to a device and method for analyzing a blood sample, particularly including pre-analytical (qualification), analytical and post-analytical (verification) testing. More particularly the disclosure relates in certain embodiments to a device configured for collecting, imaging and lysing blood cells in a sample vessel by means of ultrasonic acoustic waves, generated in the vessel by an acoustic transducer driven at one particular excitation frequency or more particular excitation frequencies, or one range of frequency or ranges of frequencies. In some non-limiting embodiments, the ultrasonic acoustic waves are generated by a single acoustic transducer. Further on, according to certain embodiments, the device and workflow are configured for three analytical steps in single device, comprising pre-analytical (qualification), analytical and post-analytical (verification) testing.

公开(公告)号：WO2022170313A1

公开(公告)日：2022-08-11

申请号：PCT/US2022/070461

申请日：2022-02-01

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： MACH, Tivadar

IPC: G01N21/76 ,  G01N21/64 ,  G01J1/58 ,  C09K11/00

Abstract: A luminescence detection system for use in immunoassay testing. Luminescence detection system comprises a sample holder configured to hold a test sample including labeled components, wherein the labeled components in the test sample undergo a chemiluminescent reaction and emit luminescent emissions over a first wavelength range, a photodetector having a light entrance window configured to receive light emissions, the photodetector having a maximum detection efficiency wavelength range, and a conversion member provided adjacent the light entrance window that operates to cause conversion of the luminescent emissions over the first wavelength range to incident emissions of a second wavelength range wherein an incident peak of the incident emissions falls within the maximum detection efficiency wavelength range where the quantum efficiency of the photodetector is 10% or more. Methods of luminescence detection are provided, as are other aspects.