公开(公告)号：WO2023089132A1

公开(公告)日：2023-05-25

申请号：PCT/EP2022/082486

申请日：2022-11-18

申请人： SMALL PHARMA LTD

发明人： RANDS, Peter ,  ROUTLEDGE, Carol ,  LAYZELL, Marie ,  JAMES, Ellen ,  JOEL, Zelah ,  BENWAY, Tiffanie ,  GOOD, Meghan

IPC分类号： A61K31/4045 ,  A61K9/00 ,  A61K9/08 ,  A61K9/19 ,  A61K47/12 ,  A61K45/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30

摘要： The present invention relates to aqueous pharmaceutical formulations, methods for their production, and uses thereof. The aqueous pharmaceutical formulations comprise a salt of an optionally substituted dimethyltryptamine compound and water, with a pH from 5 to 6.5, preferably from about 5 to about 6, and a concentration of the optionally substituted dimethyltryptamine compound of about 10 mg/ml or greater as the freebase equivalent. These formulations can comprise an effective dose of an optionally substituted dimethyltryptamine compound for use in psychedelic assisted therapy within a volume of 5 ml or less. Such formulations are surprisingly suitable both for intramuscular injection and nebulised inhalation, being both stable and clinically acceptable, and have potential uses in the treatment of psychiatric or neurological disorders.