公开(公告)号：WO2014202615A2

公开(公告)日：2014-12-24

申请号：PCT/EP2014/062736

申请日：2014-06-17

Applicant: SOPHIA GENETICS S.A.

Inventor： HUBAUX, Jean-Pierre ,  AYDAY, Erman ,  RAISARO, Jean-Louis ,  HENGARTNER, Urs ,  MOLYNEAUX, Adam ,  XU, Zhenyu ,  CAMBLONG, Jurgi ,  HUTTER, Pierre

IPC: G06F19/00

CPC classification number: G06F21/6245 ,  G06F19/28 ,  H04L9/065 ,  H04L2209/04

Abstract: A method to manage raw genomic data (SAM/BAM files) in a privacy preserving manner in a biobank. By using order preserving encryption of the reads' positions,the method provides a requested range of nucleotides to a medical unit, without revealing the locations of the short reads (which include the requested nucleotides) to the biobank. The method prevents the leakage of extra information in the short reads to the medical unit by masking the encrypted short reads at the biobank. That is, specific parts of the genomic data for which the medical unit is not authorized or the patient prefers to keep secret are masked at the biobank, without revealing any information to the biobank.

Abstract translation: 一种以生物银行的隐私保护方式管理原始基因组数据（SAM / BAM文件）的方法。 通过使用读取位置的保留加密方法，该方法向医疗单元提供所需的核苷酸范围，而不向生物银行显示短读取（包括所请求的核苷酸）的位置。 该方法通过掩盖生物银行处的加密的短读取来防止在短读中向医疗单元泄漏额外的信息。 也就是说，没有授权医疗单位或患者更喜欢保密的基因组数据的特定部分在生物银行被掩盖，而不向生物银行揭示任何信息。