公开(公告)号：WO2014015244A1

公开(公告)日：2014-01-23

申请号：PCT/US2013/051258

申请日：2013-07-19

Applicant: SORBENT THERAPEUTICS, INC.

Inventor： YOUNG, Linda De ,  CARROLL, Stephen F.

IPC: A61K31/74 ,  A61K31/755

CPC classification number: C08F220/06 ,  A61K9/14 ,  A61K31/00 ,  A61K31/74 ,  A61K31/755 ,  A61K31/78 ,  A61K45/06 ,  C08F222/1006 ,  Y10T428/2982

Abstract: The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups and pKa decreasing groups, wherein the polymer contains i) calcium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer; or ii) calcium cations and magnesium cations that are counterions to about 5% to about 75% of the carboxylic acid groups in the polymer, wherein the magnesium cations are counterions to no more than about 35% of the carboxylate groups in the polymer. The present disclosure also relates to methods of preparation of the polymers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders.

Abstract translation: 本公开一般涉及包含含有羧酸基团和pKa还原基团的单体的交联阳离子结合聚合物，其中所述聚合物包含i）与聚合物中约5％至约75％的羧酸基团的抗衡离子的钙阳离子; 或ii）与聚合物中羧酸基团的约5％至约75％的抗衡离子的钙阳离子和镁阳离子，其中镁阳离子是不超过聚合物中羧酸盐基团的约35％的抗衡离子。 本公开还涉及制备聚合物的方法，以及包含聚合物的组合物，制剂和剂型，以及使用聚合物，组合物，制剂和/或剂型来治疗各种疾病或病症的方法。