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1.发明申请TREATMENT OF CANCER USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-CD137 ANTIBODY 审中-公开使用抗PD-1抗体和抗CD137抗体组合治疗癌症
公开(公告)号：WO2016029073A3
公开(公告)日：2016-05-12
申请号：PCT/US2015046207
申请日：2015-08-21
发明人： JURE-KUNKEL MARIA , BERMAN DAVID M , KORMAN ALAN J , KRISHNAN SUBA , SELBY MARK
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2878 , C07K16/3061 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： This disclosure provides a method for treating a subject afflicted with a cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an antibody or an antigen-binding portion thereof that specifically binds to PD-1; and (b) an antibody or an antigen-binding portion thereof that specifically binds to CD137.
摘要翻译： 本公开内容提供了用于治疗罹患癌症的受试者的方法，所述方法包括向受试者施用治疗有效量的：（a）特异性结合PD-1的抗体或其抗原结合部分; 和（b）特异性结合CD137的抗体或其抗原结合部分。
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2.发明申请ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF 审中-公开抗葡萄球菌诱导的肿瘤坏死因子受体（GITR）的抗体及其用途
公开(公告)号：WO2015187835A3
公开(公告)日：2016-01-28
申请号：PCT/US2015033991
申请日：2015-06-03
发明人： WANG CHANGYU , LONBERG NILS , KORMAN ALAN J , SELBY MARK J , SRINIVASAN MOHAN , HENNING KARLA , HAN MICHELLE MINHUA , CHEN GUODONG , HUANG RICHARD , CHAKRABORTY INDRANI , HUANG HAICHUN , WONG SUSAN , LI HUIMING
CPC分类号： C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872 , G01N2333/70578
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
摘要翻译： 本文提供了结合糖皮质激素诱导型TNF受体（GITR）的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如在癌症的治疗中。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。
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