公开(公告)号：WO2014176167A3

公开(公告)日：2014-12-31

申请号：PCT/US2014034810

申请日：2014-04-21

Applicant: STERLING HEALTHCARE OPCO LLC

Inventor： STRIPP RICHARD

IPC: G01N33/50 ,  G01N21/80 ,  G01N33/84

CPC classification number: G01N30/86 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  A61B2010/0009 ,  G01N30/7233 ,  G01N30/8675 ,  G01N33/48714 ,  G01N2030/009 ,  G01N2030/085

Abstract: Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration.

Abstract translation: 用于药物检测的口服液比其他标本有几个优点：（1）可以非侵入性，直接监控; （2）药物浓度反映血药浓度; 和（3）可以通过常规药物筛选和确认方法进行处理。 该技术提供了一种测量口服液体样品中药物数量（不需要药物的先验知识）的系统，并将该水平转换为血浆药物浓度。 该方法首先测量口服液体样品中药物的浓度。 接下来，处理器根据测量的口服液体药物浓度计算血浆浓度。 最后，使用该血浆药物水平来计算总体药物浓度。