公开(公告)号：WO2021038540A

公开(公告)日：2021-03-04

申请号：PCT/IB2020/058106

申请日：2020-08-31

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED [IN]/[IN]

Inventor： RATHOD, Rajendrasinh Jashvantsinh ,  RAUT, Virendra Narendra ,  ΒΗΑΤΤ, Tushar Bhupendrabhai ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  JARAG, Tushar Mukund ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  C07D473/34 ,  C07D239/48 ,  A61K31/505 ,  A61K31/519 ,  A61K31/522 ,  A61P35/00

Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).