公开(公告)号：WO2019155389A1

公开(公告)日：2019-08-15

申请号：PCT/IB2019/050971

申请日：2019-02-06

Applicant: TARGET ONCOLOGY INC.

Inventor： BARTOSIEWICZ, Marian ,  TRAUGER, Richard ,  EADES, John Ashley

IPC: A61K45/08 ,  A61K47/36 ,  A61K31/352 ,  A61K47/38 ,  A61P31/00 ,  A61P29/00

Abstract: The present invention relates to an aqueous mucoadhesive and bioadhesive composition for the treatment of mucosal diseases, and the use of these compositions to coat mucocutaneous surfaces, such as those in the oral cavity, nasal cavity, gastrointestinal and respiratory tracts, eye, vagina, and bladder, etc. to prevent and/or treat mucosal diseases and disorders, including those which are painful, ulcerative, inflammatory, and/or erosive. The dosage forms are compositions sufficiently used to coat a wide area of the mucosal surface, but are also bioadhesive and mucoadhesive useful to provide prolonged retention on the surface of the mucosa. The compositions from liquid to solid may be used without a known pharmaceutically active compound. One or more pharmaceutically active compounds may be included in the formulation to provide additional benefit in the topical treatment of diseases, disorders and conditions of the mucosa, or for drug delivery through the mucosa to the systemic circulation.