公开(公告)号：WO02085951A3

公开(公告)日：2003-02-06

申请号：PCT/US0149827

申请日：2001-10-19

Applicant: TECHNOLOGY RESOURCE INT CORP

Inventor： HUNG WILLIAM M ,  BERGBAUER KATRINA L ,  SU KAI C ,  WANG GUIGUI

IPC: A61K9/00 ,  A61K47/36 ,  A61L12/14 ,  C08L5/08 ,  C08B37/08 ,  A61L2/18

CPC classification number: C08L5/08 ,  A61L12/14

Abstract: The present invention is directed to a water soluble, randomly substituted partial n-, partial o- acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.

Abstract translation: 本发明涉及水溶性，随机取代的部分正 - 部分O-乙酰化壳聚糖或壳聚糖衍生物和制备水溶性，随机取代的部分N-部分O-乙酰化壳聚糖或壳聚糖衍生物的方法，包括以下步骤：将 壳聚糖或壳聚糖衍生物转化成酸性水溶液，并在相转移试剂存在下使壳聚糖或壳聚糖衍生物与乙酰化剂反应。 包括：（a）至少一种壳聚糖或壳聚糖衍生物和（b）至少一种缓冲溶液，以及使用这种组合物保存隐形眼镜溶液和消毒隐形眼镜的方法。