公开(公告)号：WO2020018868A1

公开(公告)日：2020-01-23

申请号：PCT/US2019/042525

申请日：2019-07-19

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： DAS, Hiranmoy ,  RUSH, Sloan, W.

IPC: A61K35/12 ,  A61K8/64 ,  A61K35/28 ,  A61K35/33 ,  A61K8/98

Abstract: The present invention includes compositions and method of generating human corneal epithelial stem cells, a human corneal epithelial stem cell supernatant, or both, the method comprising: wetting and mincing a corneal epithelial sample in a media, drying the minced corneal epithelial sample until sample edges are adhered to a substrate, adding a growth media comprising fetal bovine serum or equivalent to the minced corneal epithelial sample without dislodging the minced corneal epithelial sample from the substrate with an amount of media that permits at least a portion of the minced corneal epithelial sample to be in contact with air, culturing the minced corneal epithelial sample for one or more days, changing the growth media to a media comprising a human corneal growth supplement (HCGS) with no fetal bovine serum, culturing the cells to grow human corneal epithelial stem cells, a human corneal epithelial stem cell supernatant, or both.

公开(公告)号：WO2019241462A1

公开(公告)日：2019-12-19

申请号：PCT/US2019/036878

申请日：2019-06-13

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： DAS, Hiranmoy

IPC: A61K35/12 ,  A61K35/32 ,  A61K35/35 ,  A61K38/18 ,  A61K38/38 ,  A61K38/40 ,  A01N1/02 ,  C12N5/071 ,  C12N5/073 ,  C12N5/077

Abstract: In one particular embodiment, the present invention uses dental pulp-derived stem cells for the treatment of osteoporosis. In one particular embodiment, the present invention uses dental pulp-derived stem cells for the treatment of ischemic stroke. In one particular embodiment, the present invention uses dental pulp-derived stem cells for the reduction of inflammations associated with inflammatory bowel disease.