公开(公告)号：WO2014047598A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/061265

申请日：2013-09-24

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： JOHNSON, Bradley, J.

IPC: G01N33/53 ,  G01N33/48 ,  G01N33/68

CPC classification number: A61K38/177 ,  A01K67/027 ,  A01K2207/05 ,  A01K2207/25 ,  A01K2227/101 ,  A01K2267/02 ,  A23K20/10 ,  A23K20/147 ,  A23K20/153 ,  A23K20/158 ,  A23K20/163 ,  A23K50/10 ,  A23K50/20 ,  A23K50/30 ,  A23K50/40 ,  A23K50/75 ,  A61K9/127 ,  A61K45/00 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention includes compositions and method of selectively modulating an intramuscular adipose tissue in beef cattle by providing a beef cattle and providing a pharmacologically effective amount of one or more agents that interact with a GPR43 receptor in the beef cattle, wherein the one or more agents modulate the GPR43 receptor to preferentially enhance the development of an intramuscular adipose tissue in the beef cattle but has no effect on subcutaneous adipose tissue accumulation in the beef cattle.

Abstract translation: 本发明包括通过提供肉牛来选择性调节肉牛的肌内脂肪组织的组合物和方法，并提供药理学有效量的一种或多种与肉牛中的GPR43受体相互作用的试剂，其中所述一种或多种试剂 调节GPR43受体以优先增强肉牛肌肉内脂肪组织的发育，但对肉牛中的皮下脂肪组织积累没有影响。