公开(公告)号：WO2019191682A1

公开(公告)日：2019-10-03

申请号：PCT/US2019/024995

申请日：2019-03-29

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： PRIEN, Samuel, D. ,  PENROSE, Lindsay, L. ,  WESSELS, Cara, E.

IPC: G01N33/483 ,  C12N5/073

Abstract: Disclosed is a system and device for determining sex of an embryo utilizing a non-invasive grading of early stage embryos (pre-hatching) based upon specific gravity, density and/or estimated weight. The device comprises a drop chamber having a lumen, capable of assessing characteristics of at least one embryo while descending. The system allows 100% recovery of embryos. A processor is further capable of performing assessment of the embryos. The disclosed system supports a wide variety of scenarios for human and animal reproductive technologies and related products and services.

公开(公告)号：WO2008088601A2

公开(公告)日：2008-07-24

申请号：PCT/US2007/083235

申请日：2007-10-31

Applicant: TEXAS TECH UNIVERSITY SYSTEM ,  PRIEN, Samuel, D. ,  PENROSE, Lindsay, L.

Inventor： PRIEN, Samuel, D. ,  PENROSE, Lindsay, L.

IPC: C12N5/06

CPC classification number: C12M47/04 ,  C12N5/0612

Abstract: The present invention includes methods and apparatus to separate X or Y-chromosome bearing sperm cells in a population by first placing the population of sperm cells at physiological pH environment, and simultaneously contacting the population of sperm cells with one or more additional sub-environments with different pH values. The exposure allows mobile sperm cells bearing X or Y-chromosome to migrate to the different pH sub-environments, wherein each cell only exposed or come in contact with one pH sub-environment. Finally, the collecting X or Y- chromosome enriched population of sperm cells is performed.

Abstract translation: 本发明包括通过首先将精子细胞群体置于生理pH环境中来分离群体中携带X或Y染色体的精子细胞的方法和装置，同时使精子细胞群与一个或多个其它亚环境接触， 不同的pH值。 暴露允许携带X或Y染色体的移动精子细胞迁移到不同的pH亚环境，其中每个细胞仅暴露或与一个pH亚环境接触。 最后，进行收集X或Y染色体富集的精子细胞群体。