公开(公告)号：WO2020248075A1

公开(公告)日：2020-12-17

申请号：PCT/CA2020/050823

申请日：2020-06-12

Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

Inventor： WEST, Frederick ,  TUSZYNSKI, Jack ,  WEINFELD, Michael ,  BARAKAT, Khaled Hassan ,  ELMENOUFY, Ahmed H. ,  GENTILE, Francesco ,  KARIMI-BUSHERI, Feridoun ,  WEILBEER, Claudia

IPC: C07D219/10 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/495 ,  A61P35/00 ,  C07D215/44 ,  C07D219/04 ,  C07D295/135 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

Abstract: The current application relates to pyronaridine or 6-chloro-2-methoxyacridine analogs having binding affinity for the ERCC1-XPF hetero-dimerization interface. The compounds can be used for targeting DNA repair in tumor cells via ERCC1-XPF inhibition, therefore improving the therapeutic benefit of irradiation or other cancer treatment, or reducing the dosage and adverse effects associated with such treatment.