专利检索 ap:("THE J. DAVID GLADSTONE INSTITUTES") AND inv:"WEINBERGER, Leor" 第 1 页

1.

发明申请
COMPOSITIONS FOR HERPESVIRUS TRANSCRIPTIONAL FEEDBACK CIRCUIT DISRUPTION AND USES THEREOF 审中-公开

公开(公告)号：WO2019241435A1

公开(公告)日：2019-12-19

申请号：PCT/US2019/036841

申请日：2019-06-12

申请人： THE J. DAVID GLADSTONE INSTITUTES

发明人： WEINBERGER, Leor , CHATURVEDI, Sonali

IPC分类号： A61K31/711 , A61K31/713 , A61K39/12 , A61K39/245 , C07H21/04 , C12Q1/68 , C12Q1/70

摘要： The present disclosure provides compositions and methods for inhibiting herpesvirus replication in a cell infected with herpesvirus. The composition includes a double stranded DNA molecule including a sequence of a cis regulatory sequence (crs) of a herpesvirus, wherein the crs is flanked on the 5' end by a first sequence of at least 2 base pairs and on the 3' end by a second sequence of at least 2 base pairs.

2.

发明申请
COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF 审中-公开
标题翻译：用于基因表达筛选的组合物，系统和方法及其用途

公开(公告)号：WO2015051035A1

公开(公告)日：2015-04-09

申请号：PCT/US2014/058687

申请日：2014-10-01

申请人： THE J. DAVID GLADSTONE INSTITUTES

发明人： WEINBERGER, Leor , DAR, Roy

IPC分类号： C12Q1/70

CPC分类号： G01N33/5023 , A61K31/22 , A61K31/496 , A61K38/191 , C12Q1/6897 , C12Q1/703 , G01N2333/16

摘要： HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency.

摘要翻译： HIV-1进入转录状态并建立潜伏感染细胞的水平的能力被认为是根除病毒感染患者的主要障碍。 HIV-1转录阳性反馈环路中的随机噪声（即波动）是使HIV-1建立潜伏期的一种机制。在这里，申请人表明HIV-1基因表达中的小分子调节噪声基本上扰乱了HIV-1潜伏期。