公开(公告)号：WO2021252777A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036834

申请日：2021-06-10

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： FELIX, Jamie, B. ,  CHAKI, Sankar, P. ,  COOK, Walt, E. ,  FICHT, Allison ,  FICHT, Thomas, A.

IPC: A16K9/16 ,  A16P37/04 ,  A16K39/39 ,  C07K16/12 ,  A61K39/07

Abstract: Methods and compositions for the immunization of animals and humans using an oral immunization or vaccine that comprises B. anthracis Sterne strain 34F2 spores suspended in alginate and coated with a shell containing poly-L-lysine (PEL), a vitelline protein B (VpB), or both and an external coating of alginate in an amount sufficient to protect an animal or human from a lethal dose of anthrax.