公开(公告)号：WO2022094079A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/057048

申请日：2021-10-28

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： GILL, Nicholas, P. ,  MADDEN, Dean, R. ,  CHEVEZ, Moises ,  AL-AYYOUBI, Sahar ,  CUSHING, Patrick, R. ,  ZHAO, Yu

IPC分类号： A61K31/05 ,  A61K31/122 ,  A61K31/136 ,  A61K31/18 ,  A61K31/192 ,  A61K31/216 ,  A61K31/327 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/395 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4196 ,  A61K31/435 ,  A61K31/50 ,  A61K31/5355 ,  A61K31/65 ,  A61K45/06 ,  A61P11/00

摘要： This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases associated with interaction of proteins with PDZ domain of the CFTR-associated ligand (CAL PDZ or CALP) and/or DH domain on Disabled-2 (Dab2) protein (Dab2-DH). More particularly, this disclosure relates to methods of treating cystic fibrosis.