公开(公告)号：WO2022165058A1

公开(公告)日：2022-08-04

申请号：PCT/US2022/014128

申请日：2022-01-27

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： GUO, Feng ,  CAI, Hongwei

IPC: G10K11/02 ,  G10K11/08

Abstract: Disclosed are methods and systems for implementing dynamic control of acoustic fields, which involves the use of machine learning through a Markov Decision Process. The machine learning algorithm monitors an attribute of a system and maintains the attribute within a range by altering a signal sent to an acoustic transducer. The acoustic transducer is configured to alter the attribute of the system. The attribute may be an attribute of the acoustic field produced by the acoustic transducer, or may be an attribute of another element of the system, such as a fluid, a rotor, or a cell mass.

公开(公告)号：WO2022240928A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028682

申请日：2022-05-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： GUO, Feng ,  XU, Junhua ,  CAI, Hongwei

IPC: A61M37/00

Abstract: Disclosed is a system for therapeutic delivery. The system includes a microneedle patch and an acoustic transducer configured to alter the delivery of the therapeutic from the patch. The acoustic parameters may be determined from a therapeutic release model. The system may also be contained within a housing which may be at least partially removed to deliver the therapeutic. The transducer provides control over the delivery of the therapeutic.

公开(公告)号：WO2022155337A1

公开(公告)日：2022-07-21

申请号：PCT/US2022/012313

申请日：2022-01-13

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： GUO, Feng ,  AO, Zheng ,  CAI, Hongwei

IPC: C12M3/00

Abstract: Disclosed is an apparatus configured to support growth of a 3D, hollow organoid. The apparatus contains a support structure and an enclosure, wherein a number of cells positioned between the support structure and the enclosure can grow on/around the support structure to form the organoid. The support structure additionally contains openings such that a fluid within the structure can flow into the organoid. The support structure may also extend between two fluid reservoirs configured to supply a fluid to the structure and organoid. The entire apparatus may be formed from an additive manufacturing process.

公开(公告)号：WO2020198455A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/024927

申请日：2020-03-26

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： GUO, Feng

IPC: C12M1/12 ,  C12N5/00 ,  B33Y70/00 ,  B01L3/00 ,  B01L9/00

Abstract: Disclosed is an apparatus, such as an acoustofluidic device, for high-throughput fabrication of multicellular spheroids. The device has a chamber substrate having at least one cell assembly channel; an acoustic transducer; and, a coupling layer disposed between the chamber substrate and the acoustic transducer.