公开(公告)号：WO2020247725A1

公开(公告)日：2020-12-10

申请号：PCT/US2020/036285

申请日：2020-06-05

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY ,  MRL CAMBRIDGE ESC

发明人： MACMILLAN, David, W.C. ,  GERI, Jacob ,  WANG, Tao ,  OAKLEY, James ,  REYES-ROBLES, Tamara ,  OSLUND, Rob, C. ,  FADEYI, Olugbeminiyi, O. ,  PARKER, Dann, Leroy ,  RODRIGUEZ-RIVERA, Frances, Paola ,  McCARVER, Stefan

IPC分类号： B22F1/00 ,  B22F1/02 ,  C22C1/05

摘要： In one aspect, compositions and methods are described herein for providing a microenvironment mapping platform operable to selectively identify various features, including protein-protein interactions on cellular membranes. In some embodiments, a composition comprises a catalyst, and a protein labeling agent, wherein the catalyst activates the protein labeling agent to a reactive intermediate. The catalyst, in some embodiments, can have electronic structure for permitting energy transfer to the protein labeling agent to form the reactive intermediate. The reactive intermediate reacts or crosslinks with a protein or other biomolecule within the diffusion radius of the reactive intermediate.