公开(公告)号：WO1996036368A2

公开(公告)日：1996-11-21

申请号：PCT/US1996006439

申请日：1996-05-08

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  MARCOLONGO, Michele, S. ,  DUCHEYNE, Paul ,  KO, Frank ,  LACOURSE, William

IPC: A61L00/00

CPC classification number: C03C4/0007 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/367 ,  A61F2002/30289 ,  A61F2002/3082 ,  A61F2230/0091 ,  A61L27/025 ,  A61L27/10 ,  A61L27/422 ,  A61L27/443 ,  A61L27/446 ,  C03C13/00 ,  C03C2213/02 ,  D03D9/00 ,  D03D15/00 ,  D03D15/0011 ,  D03D15/0027 ,  D10B2101/06 ,  D10B2101/08 ,  D10B2101/12 ,  D10B2331/021 ,  D10B2401/041 ,  D10B2401/061 ,  D10B2401/063 ,  D10B2509/00 ,  Y10T428/29 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2964 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  Y10T428/2973 ,  Y10T428/2978 ,  Y10T428/30 ,  Y10T442/3049 ,  Y10T442/3236 ,  A61F2/28 ,  C08L81/06 ,  C08L71/12

Abstract: Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30 % bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Further preferred bioactive materials include aluminum oxide at greater than 0.2 %, by mole. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.

Abstract translation: 公开了由骨生物活性玻璃或陶瓷纤维和结构纤维形成的复合材料。 在优选的实施方案中，用聚合物材料浸渍交织的骨生物活性玻璃或陶瓷纤维和结构纤维的编织物或网，以提供合适的生物相容性和结构完整性的复合材料。 最优选地，网或编织物被设计成使得生物活性纤维集中在植入物的表面以产生由至少30％的生物活性材料组成的表面，从而提供增强的骨向内生长。 骨生物活性玻璃或陶瓷纤维与结构纤维芯之间的交织克服了现有复合体系中发现的问题，其中生物活性材料从聚合物分层。 优选的生物活性材料包括磷酸钙陶瓷，优选的结构纤维包括碳纤维。 进一步优选的生物活性材料包括大于0.2％（摩尔）的氧化铝。 因此，还公开了改进的假体植入物和固定植入物的方法。

公开(公告)号：WO1995014127A1

公开(公告)日：1995-05-26

申请号：PCT/US1994013152

申请日：1994-11-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  MARCOLONGO, Michele, S. ,  DUCHEYNE, Paul ,  KO, Frank ,  LACOURSE, William

IPC: D03D03/00

CPC classification number: C03C4/0007 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/367 ,  A61F2002/30289 ,  A61F2002/3082 ,  A61F2230/0091 ,  A61L27/025 ,  A61L27/10 ,  A61L27/422 ,  A61L27/443 ,  A61L27/446 ,  C03C13/00 ,  C03C2213/02 ,  D03D9/00 ,  D03D15/00 ,  D03D15/0011 ,  D03D15/0027 ,  D10B2101/06 ,  D10B2101/08 ,  D10B2101/12 ,  D10B2331/021 ,  D10B2401/041 ,  D10B2401/061 ,  D10B2401/063 ,  D10B2509/00 ,  Y10T428/29 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2964 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  Y10T428/2973 ,  Y10T428/2978 ,  Y10T428/30 ,  Y10T442/3049 ,  Y10T442/3236 ,  A61F2/28 ,  C08L81/06 ,  C08L71/12

Abstract: Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant (200) to create a surface comprised of at least 30 % bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Improved prosthetic implants (200) and methods of affixing an implant (200, are thus also disclosed.

Abstract translation: 公开了由骨生物活性玻璃或陶瓷纤维和结构纤维形成的复合材料。 在优选的实施方案中，用聚合物材料浸渍交织的骨生物活性玻璃或陶瓷纤维和结构纤维的编织物或网，以提供合适的生物相容性和结构完整性的复合材料。 最优选地，网或编织物被设计成使得生物活性纤维在植入物（200）的表面处集中以产生由至少30％的生物活性材料组成的表面，从而提供增强的骨向内生长。 骨生物活性玻璃或陶瓷纤维与结构纤维芯之间的交织克服了现有复合体系中发现的问题，其中生物活性材料从聚合物分层。 优选的生物活性材料包括磷酸钙陶瓷，优选的结构纤维包括碳纤维。 改进的假体植入物（200）和固定植入物的方法（200，因此也被公开。