公开(公告)号：WO2018102774A3

公开(公告)日：2018-07-12

申请号：PCT/US2017064347

申请日：2017-12-01

申请人： THE UAB RES FOUNDATION ,  UNIV TOKYO

发明人： BRILES DAVID E ,  KIYONO HIROSHI ,  KNELLER ROBERT ,  MUKERJI RESHMI ,  GENSCHMER KRISTOPHER ,  YUKI YOSHIKAZU

IPC分类号： A61K39/09 ,  A61P31/04

CPC分类号： A61K39/092 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61P31/04 ,  C07K2319/40

摘要： The present embodiments provide compositions and methods related to novel recombinant protein immunogens, comprising specific portions of alpha helical domains (aHD) and proline rich regions (PRD) of pneumococcal surface protein A (PspA), which portions are linked to provide aHD-PRD constructs. The aHD and PRD proteins constituting the aHD-PRD constructs are selected to maximize cross-reactivity and provide protection against a broad spectrum of pneumococcal serotypes. Immunogenic compositions, including vaccines, comprising at least one aHD PRD construct may also include a non-linked aHD portion. Also provided are recombinant nucleic acid molecules that encode aHD-PRD constructs, vectors and recombinant host cells containing such molecules, aHD-PRD expression products, use of such nucleic acid molecules to express aHD-PRD constructs by recombinant techniques, and use of the expression products to elicit an immune or protective response against pneumococcal disease in a suitable host.