专利检索 ap:("THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL") AND inv:"CHIARELLA, Anna" 第 1 页

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发明申请
BIFUNCTIONAL CHEMICAL EPIGENENTIC MODIFIERS AND METHODS OF USE 审中-公开

公开(公告)号：WO2019028426A1

公开(公告)日：2019-02-07

申请号：PCT/US2018/045266

申请日：2018-08-03

申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： HATHAWAY, Nate , JIN, Jian , BUTLER, Kyle , CHIARELLA, Anna

IPC分类号： C12N15/09 , C12N9/22 , C07K14/435

CPC分类号： C12N9/80 , C12N9/90 , C12Y305/01098 , C12Y502/01

摘要： The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.