公开(公告)号：WO2014143676A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/027737

申请日：2014-03-14

Applicant: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： KORENBERG, Julie Ruth ,  WILCOX, Karen Sue ,  WEST, Peter Jeffrey ,  KESNER, Raymond Pierre

IPC: A01N43/58 ,  A01N43/60

CPC classification number: A61K31/505 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K45/06 ,  C07D209/14 ,  C07D239/50 ,  C07D295/096 ,  C07D401/04 ,  C07D401/10 ,  C07D487/04

Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT 6 ) receptor antagonists are provided for improving the cognition of a Down syndrome patient.

Abstract translation: 公开了治疗唐氏综合症和提高智力障碍患者认知功能的方法。 提供5-羟色胺亚受体六（5-HT6）受体拮抗剂用于改善唐氏综合症患者的认知。

公开(公告)号：WO2014165701A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/032876

申请日：2014-04-03

Applicant: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： KORENBERG, Julie Ruth ,  WILCOX, Karen Sue ,  WEST, Peter Jeffrey ,  KESNER, Raymond Pierre

IPC: A61P25/28

CPC classification number: A61K31/505 ,  A61K31/165 ,  A61K31/27 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4425 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/55 ,  A61K31/63 ,  A61K45/06

Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT 6) receptor antagonists are provided for improving the cognition of a Down syndrome patient. Through the use of a mouse model of DS, the Ts65Dn mouse, we disclose evidence herein that 5-HT 6 receptor antagonists may alleviate the cognitive deficits observed in human subjects suffering from DS. Species within the claimed genus of 5-HT6 receptor antagonists restored the cognitive function of Ts65Dn mice almost to the level of control mice as demonstrated by an improved ability to differentiate between a familiar object in a familiar location and a novel object in a novel location. Consequently, the data disclosed herein support the claimed use of 5-HT 6 receptor antagonists for the treatment of cognitive deficits associated with DS.

Abstract translation: 公开了治疗唐氏综合症和提高智力障碍患者认知功能的方法。 提供5-羟色胺亚受体六（5-HT 6）受体拮抗剂用于改善唐氏综合征患者的认知。 通过使用DS的小鼠模型Ts65Dn小鼠，我们在此披露了5-HT 6受体拮抗剂可以缓解在患有DS的人类受试者中观察到的认知缺陷的证据。 所要求的5-HT6受体拮抗剂类别中的物种将Ts65Dn小鼠的认知功能恢复到对照小鼠的水平，如通过改善在熟悉位置中熟悉的物体和新颖位置中的新物体之间的区分的能力所证明的。 因此，本文公开的数据支持要求使用5-HT 6受体拮抗剂治疗与DS相关的认知缺陷。