公开(公告)号：WO2022189861A1

公开(公告)日：2022-09-15

申请号：PCT/IB2022/000123

申请日：2022-03-08

申请人： TOLLYS

发明人： BONNIN, Marc ,  GUILLOT-CHENE, Philippe ,  RIGAL, Dominique

IPC分类号： C12N15/117

摘要： The present technology relates to conjugates, or pharmaceutically acceptable salts thereof, comprising a carbohydrate covalently linked to a double-stranded RNA. The double-stranded RNA comprised in the conjugate has a sense strand and an antisense strand, wherein the sense strand comprises at least one block of poly A comprising at least 15 A, and the antisense strand comprises at least one complementary block poly U comprising at least 15 U, and each of the sense and antisense strands have a length of between 50 and 200 nucleotides. The present technology further relates to pharmaceutical compositions comprising the conjugates of the present technology for use, and methods of use thereof, for the treatment of subjects having an HBV infection, HBV-associated disorder and/or hepatocellular carcinoma.