公开(公告)号：WO2016076780A1

公开(公告)日：2016-05-19

申请号：PCT/SE2015/051188

申请日：2015-11-10

Applicant: TX MEDIC AB

Inventor： BRUCE, Lars ,  BRASEN, Ulf

IPC: A61K31/737 ,  C08B37/02 ,  A61P7/02

CPC classification number: C08L5/02 ,  C08B37/0021 ,  C08L2203/02

Abstract: A dextran sulfate, or a salt thereof, has a number average molecular weight (Mn) as measured by NMR spectroscopy within an interval of 1850 and 3500 Da. The dextran sulfate, or the salt thereof, also has an average sulfate number per glucose unit within an interval of 2.5 and 3.0. Furthermore, an average sulfation of C2 position in the glucose units of the dextran sulfate, or the salt thereof, is at least 90 %. The dextran sulfate has improved biological effects and/or reduced toxicity as compared to similar dextran sulfate molecules available on the market.

Abstract translation: 硫酸葡聚糖或其盐具有在1850和3500Da的间隔内通过NMR光谱测量的数均分子量（Mn）。 硫酸葡聚糖或其盐在2.5和3.0的间隔内也具有每个葡萄糖单元的平均硫酸根数。 此外，硫酸葡聚糖或其盐的葡萄糖单元中C2位置的平均硫酸化为至少90％。 与市售的类似的硫酸葡聚糖分子相比，硫酸葡聚糖具有改善的生物效应和/或降低的毒性。