公开(公告)号：WO1992008466A1

公开(公告)日：1992-05-29

申请号：PCT/US1991008366

申请日：1991-11-08

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  ESKO, Jeffery, D. ,  LUGEMWA, Fulgentius, N.

IPC: A61K31/58

CPC classification number: A61K31/58 ,  A61K31/70

Abstract: Conjugates of β-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.

公开(公告)号：WO1994005678A1

公开(公告)日：1994-03-17

申请号：PCT/US1993008189

申请日：1993-08-31

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： THE UAB RESEARCH FOUNDATION ,  ESKO, Jeffrey, D. ,  LUGEMWA, Fulgentius, N. ,  FRITZ, Timothy, A.

IPC: C07G03/00

CPC classification number: C07H15/203 ,  C07H15/04 ,  C07H17/02 ,  C07H17/04 ,  C07J17/005

Abstract: Compounds comprising a first aromatic ring linked to a xylose via a hydroxyl, thio, hydrocarbon, or amino substituent to form a (beta)-D-xyloside linkage and a second aromatic ring fused to the first ring are useful primers for the biosynthesis of heparan sulfate and can suppress (in vivo) growth of smooth muscle cells.

Abstract translation: 包含通过羟基，硫代，烃基或氨基取代基与木糖连接以形成（β）-D-木糖苷键和与第一环稠合的第二芳环的第一芳环的化合物是用于生物合成肝素的有用引物 硫酸盐并能抑制（体内）平滑肌细胞的生长。