公开(公告)号：WO1997035588A1

公开(公告)日：1997-10-02

申请号：PCT/US1997004841

申请日：1997-03-25

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  WELLS, Alan ,  CHEN, Philip ,  TURNER, Timothy

IPC: A61K31/66

CPC classification number: A61K31/685 ,  A61K31/15 ,  A61K31/27 ,  A61K31/58

Abstract: The present invention provides a method of inhibiting tumor progression in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Also provided is a method of inhibiting metastasis in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Further provided are pharmaceutical compositions, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis and a pharmaceutically acceptable carrier and a pharmaceutical composition, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis, an antineoplastic agent and a pharmaceutically acceptable carrier.

Abstract translation: 本发明提供抑制需要这种治疗的个体中肿瘤进展的方法，包括向所述个体施用药理学有效剂量的磷脂酶C抑制剂的步骤。 还提供了在需要这种治疗的个体中抑制转移的方法，包括向所述个体施用药理学有效剂量的磷脂酶C抑制剂的步骤。 还提供了包含肿瘤侵袭和转移的磷脂酶C抑制剂和药学上可接受的载体和药物组合物的药物组合物，其包含肿瘤侵袭和转移的磷脂酶C抑制剂，抗肿瘤剂和药学上可接受的载体。