公开(公告)号：WO9317031A3

公开(公告)日：1993-12-23

申请号：PCT/US9301560

申请日：1993-02-19

Applicant: UNIV IOWA RES FOUND

Inventor： CAMPBELL KEVIN P ,  IBRAGHIMOV-BESKROVNAYA OXANA ,  ERVASTI JAMES M ,  LEVEILLE CYNTHIA J ,  MATSUMURA KIICHIRO

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C12N15/12 ,  G01N33/68 ,  C07H

CPC classification number: C07K14/4707 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4708 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N2800/2878 ,  G01N2800/2885

Abstract: The subject disclosure relates to substantially pure nucleic acid sequences encoding at least a portion of a dystrophin-associated protein. Deoxyribonucleic acid can be expressed in a DNA expression construct. Protein produced in this manner can be used for a variety of purposes including immunization to produce antibodies. Such DNA expression constructs, and the protein encoded by same, are useful in therapeutic methods to complement a genetic defect which results in muscular dystrophy.