公开(公告)号：WO2006105279A9

公开(公告)日：2007-01-25

申请号：PCT/US2006011617

申请日：2006-03-29

Applicant: UNIV NEW YORK ,  HURTADO ALICIA ,  MERUELO DANIEL

Inventor： HURTADO ALICIA ,  MERUELO DANIEL

IPC: A61K48/00

CPC classification number: C12N7/00 ,  A01K2267/0331 ,  A61K35/76 ,  C07K14/005 ,  C12N15/86 ,  C12N2770/36122 ,  C12N2770/36132 ,  C12N2770/36143 ,  C12N2770/36161 ,  C12N2840/203

Abstract: Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods.

Abstract translation: 本文公开了由野生型Ar-339辛德毕斯病毒制备的新的有缺陷的辛德比斯病毒载体，其在JT载体和共有的辛德比斯病毒序列之间以及JT和Ar-339载体之间具有复制酶和包膜蛋白的差异。 还公开了用于生产载体的质粒，用于生产载体的方法，用于治疗患有肿瘤的哺乳动物的方法和用于治疗方法的药物制剂。

公开(公告)号：WO2006105279A2

公开(公告)日：2006-10-05

申请号：PCT/US2006011617

申请日：2006-03-29

Applicant: UNIV NEW YORK ,  HURTADO ALICIA ,  MERUELO DANIEL

Inventor： HURTADO ALICIA ,  MERUELO DANIEL

IPC: A61K48/00

CPC classification number: C12N7/00 ,  A01K2267/0331 ,  A61K35/76 ,  C07K14/005 ,  C12N15/86 ,  C12N2770/36122 ,  C12N2770/36132 ,  C12N2770/36143 ,  C12N2770/36161 ,  C12N2840/203

Abstract: Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods.

Abstract translation: 本文公开了由野生型Ar-339辛德毕斯病毒制备的新的有缺陷的辛德比斯病毒载体，其在JT载体和共有的辛德比斯病毒序列之间以及JT和Ar-339载体之间具有复制酶和包膜蛋白的差异。 还公开了用于生产载体的质粒，用于生产载体的方法，用于治疗患有肿瘤的哺乳动物的方法和用于治疗方法的药物制剂。

公开(公告)号：WO2010005704A3

公开(公告)日：2010-08-26

申请号：PCT/US2009047394

申请日：2009-06-15

Applicant: UNIV NEW YORK ,  HURTADO ALICIA ,  MERUELO DANIEL

Inventor： HURTADO ALICIA ,  MERUELO DANIEL

IPC: C12N15/63 ,  A61K48/00 ,  A61P35/00 ,  C12N15/85

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N2770/36122 ,  C12N2770/36143

Abstract: Disclosed herein are new defective Sindbis viral vectors made from a novel Helper plasmid, with differences in envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are vectors produced using the plasmid, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods.

Abstract translation: 本文公开了由新型辅助质粒制备的新的缺陷辛德毕斯病毒载体，其在JT载体和共有辛德毕斯病毒序列之间以及JT和Ar-339载体之间的包膜蛋白中存在差异。 还公开了使用该质粒产生的载体，制备该载体的方法，治疗患有肿瘤的哺乳动物的方法和用于治疗方法的药物制剂。