公开(公告)号：WO2007085026A3

公开(公告)日：2007-11-22

申请号：PCT/US2007060870

申请日：2007-01-22

Applicant: UNIV TEXAS ,  LEVIN VICTOR A ,  MENDEL EBUD

Inventor： LEVIN VICTOR A ,  MENDEL EBUD

IPC: A01N25/00 ,  A61F2/00

CPC classification number: A61K49/0438 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/045 ,  A61K45/06 ,  A61K47/10 ,  A61K47/20 ,  A61K49/0433 ,  A61K49/0452 ,  A61K49/06 ,  A61K2300/00

Abstract: The present invention provides methods for the treatment of tumors, such as spinal metastases, using compositions that permit the introduction of chemotherapeutics intratumorally while concurrently visualizing the procedure. Thus, in certain embodiments, the invention concerns a composition comprising a chemotherapeutic, an alcohol and an iodinated contrast agent (e.g., iodouracil) that may be introduced into the tumor by direct injection through the aid of an imaging device, such as a CT scanner, x-ray machine, fluoroscope or the like. The ability to visualize drug solution permits the faithful introduction of the drug directly into the tumor, as opposed to surrounding tissues, which is enabled through the use of the contrast medium.

Abstract translation: 本发明提供了使用组合物治疗肿瘤例如脊柱转移瘤的方法，所述组合物允许瘤内引入化学治疗剂，同时可视化该方法。 因此，在某些实施方案中，本发明涉及包含化学治疗剂，醇和碘化造影剂（例如碘尿嘧啶）的组合物，其可通过借助成像装置例如CT扫描仪直接注射引入肿瘤 ，X光机，荧光镜等。 可视化药物溶液的能力允许将药物直接引入肿瘤中，而不是通过使用造影剂使周围组织发生变化。