公开(公告)号：WO2013075248A9

公开(公告)日：2014-12-18

申请号：PCT/CA2012050847

申请日：2012-11-23

Applicant: UNIV TORONTO

Inventor： GUENTHER AXEL ,  LENG LIAN ,  WOLLARD ANDREW ,  MCALLISTER ARIANNA ,  RADISIC MILICA ,  ZHANG BOYANG

IPC: B81B1/00 ,  A23G3/00 ,  A61K8/72 ,  A61K35/12 ,  C08J5/18 ,  C12M1/34 ,  C12M3/00 ,  C12N11/02 ,  C40B60/00

CPC classification number: B29C47/0021 ,  A23G3/0002 ,  B01L3/5027 ,  C12M23/16

Abstract: Methods and devices are disclosed for providing the controlled formation of planar homogeneous or heterogeneous materials using microfluidic devices. In one embodiment, a planar array of microfluidic channels is employed to produce a flowing liquid sheet having heterogeneous structure by spatially and temporally controlling dispensing of polymer liquid from selected microchannels. The resulting liquid sheet is solidified to produce a planar heterogeneous material that may be continuously drawn and/or fed from the plurality of microfluidic channels. The polymer liquid may include a payload that may be selectively incorporated into the heterogeneous structure. In some embodiments, the local material composition is controllable, thereby allowing control over local and bulk material properties, such as the permeability and the elasticity, and of creating materials with directionally dependent properties.

Abstract translation: 公开了用于使用微流体装置提供平面均质或异质材料的受控形成的方法和装置。 在一个实施例中，使用微流体通道的平面阵列来通过空间和时间控制从选定的微通道分配聚合物液体来产生具有不均匀结构的流动液体片。 所得液体片材被固化以产生可以从多个微流体通道连续拉伸和/或进料的平面非均质材料。 聚合物液体可以包括可以选择性地结合到异质结构中的有效载荷。 在一些实施方案中，局部材料组成是可控的，从而允许控制局部和体积材料性质，例如渗透性和弹性，以及产生具有定向依赖性质的材料。